Immune Conditions & Diseases
Medical conditions affecting the immune area or system
Rheumatoid Arthritis
ModerateA chronic autoimmune disorder that primarily attacks the synovial joints, leading to inflammation and joint damage.
- Joint pain and swelling
- Morning stiffness lasting >1 hour
- Fatigue
Systemic Lupus Erythematosus
VariableA multisystem autoimmune disease characterized by the production of autoantibodies that can affect skin, kidneys, joints, and other organs.
- Butterfly facial rash
- Joint pain
- Photosensitivity
Type 1 Diabetes Mellitus
ModerateAn autoimmune destruction of pancreatic β‑cells resulting in absolute insulin deficiency.
- Polyuria
- Polydipsia
- Unexplained weight loss
Multiple Sclerosis
VariableAn immune‑mediated demyelinating disease of the central nervous system causing neurological deficits.
- Visual disturbances
- Numbness or tingling
- Muscle weakness
Hashimoto Thyroiditis
MildAn autoimmune attack on the thyroid gland leading to chronic hypothyroidism.
- Fatigue
- Weight gain
- Cold intolerance
Graves Disease
ModerateAn autoimmune disorder that stimulates the thyroid to produce excess thyroid hormone (hyperthyroidism).
- Weight loss
- Heat intolerance
- Tremor
Psoriasis
MildA chronic immune‑driven skin disease characterized by hyperproliferation of keratinocytes.
- Red scaly plaques
- Itching
- Joint pain (psoriatic arthritis)
Celiac Disease
ModerateAn autoimmune reaction to gluten that damages the small‑intestinal mucosa.
- Chronic diarrhea
- Abdominal bloating
- Weight loss
Crohn's Disease
ModerateA type of inflammatory bowel disease (IBD) causing transmural inflammation of the gastrointestinal tract.
- Abdominal pain
- Diarrhea
- Weight loss
Ulcerative Colitis
ModerateAn IBD limited to the colon and rectum, characterized by continuous mucosal inflammation.
- Bloody diarrhea
- Abdominal cramping
- Urgency to defecate
Sjögren's Syndrome
MildAn autoimmune disorder targeting exocrine glands, leading to dryness of mucosal surfaces.
- Dry eyes
- Dry mouth
- Joint pain
Myasthenia Gravis
ModerateAn antibody‑mediated disease that impairs neuromuscular transmission, causing fluctuating muscle weakness.
- Ptosis
- Difficulty swallowing
- Generalized weakness
Vitiligo
MildAn autoimmune loss of melanocytes resulting in depigmented skin patches.
- Well‑defined white patches
- Loss of pigment in hair
- Sensitivity to sunburn
Addison Disease
ModerateAutoimmune destruction of the adrenal cortex leading to cortisol and aldosterone deficiency.
- Fatigue
- Weight loss
- Hyperpigmentation
Pernicious Anemia
MildAutoimmune gastritis causing vitamin B12 malabsorption and megaloblastic anemia.
- Fatigue
- Glossitis
- Neuropathy
Autoimmune Hepatitis
ModerateChronic inflammation of the liver caused by autoantibodies against hepatic cells.
- Jaundice
- Fatigue
- Abdominal discomfort
Guillain‑Barré Syndrome
SevereAn acute autoimmune peripheral neuropathy that leads to rapid muscle weakness.
- Ascending weakness
- Tingling sensations
- Loss of reflexes
Dermatomyositis
ModerateAn inflammatory myopathy with characteristic skin findings caused by immune-mediated muscle damage.
- Heliotrope rash
- Muscle weakness
- Gottron papules
Systemic Sclerosis (Scleroderma)
ModerateAn autoimmune disease marked by fibrosis of skin and internal organs.
- Skin thickening
- Raynaud's phenomenon
- Joint pain
Ankylosing Spondylitis
ModerateA chronic inflammatory arthritis primarily affecting the spine and sacroiliac joints.
- Low back pain
- Morning stiffness
- Reduced spinal mobility
Primary Biliary Cholangitis
ModerateAutoimmune destruction of intra‑hepatic bile ducts leading to cholestasis.
- Pruritus
- Fatigue
- Jaundice
Chronic Granulomatous Disease
SevereA primary immunodeficiency where phagocytes cannot produce reactive oxygen species, causing recurrent infections.
- Frequent bacterial infections
- Granuloma formation
- Lymphadenitis
Severe Combined Immunodeficiency (SCID)
SevereA group of genetic disorders resulting in profound defects of both T‑ and B‑cell immunity.
- Severe infections early in life
- Failure to thrive
- Chronic diarrhea
Human Immunodeficiency Virus (HIV) Infection
VariableA viral infection that progressively destroys CD4+ T cells, leading to acquired immunodeficiency syndrome (AIDS).
- Persistent lymphadenopathy
- Weight loss
- Recurrent opportunistic infections
Allergic Rhinitis
MildAn IgE‑mediated hypersensitivity of the nasal mucosa to environmental allergens.
- Sneezing
- Nasal congestion
- Itchy eyes
Asthma
ModerateA chronic inflammatory airway disease driven by immune mechanisms causing reversible airflow obstruction.
- Wheezing
- Shortness of breath
- Chest tightness
Atopic Dermatitis
MildA chronic, relapsing inflammatory skin condition associated with IgE‑mediated hypersensitivity.
- Eczematous rash
- Intense itching
- Dry skin
Food Allergy
VariableAn abnormal immune response to specific food proteins, often IgE‑mediated.
- Hives
- Swelling of lips/tongue
- Vomiting
Drug Hypersensitivity
VariableImmune‑mediated adverse reactions to medications, ranging from mild rash to life‑threatening anaphylaxis.
- Rash
- Fever
- Organ involvement (e.g., liver),
Chronic Urticaria
MildPersistent hives lasting >6 weeks, often due to autoimmune activation of mast cells.
- Red wheals
- Itching
- Swelling of lips or eyelids
When to Seek Medical Help
For immune conditions, consult a healthcare provider if you experience:
- Persistent or worsening symptoms
- Sudden onset of severe symptoms
- Symptoms that interfere with daily activities
- Signs of infection (fever, swelling, redness)
- Unexplained changes or new symptoms
Medical Disclaimer
Medical Disclaimer: The information provided on this website is for general informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. If you think you may have a medical emergency, call your doctor, go to the emergency department, or call 911 immediately.