Endocrine Conditions & Diseases
Medical conditions affecting the endocrine area or system
Type 1 Diabetes Mellitus
SevereAn autoimmune destruction of pancreatic beta cells leading to absolute insulin deficiency.
- Frequent urination
- Unexplained weight loss
- Increased thirst
Type 2 Diabetes Mellitus
VariableA metabolic disorder characterized by insulin resistance and relative insulin deficiency.
- Blurred vision
- Slow healing of cuts
- Increased thirst
Hypothyroidism
Mild To ModerateUnderactive thyroid gland producing insufficient thyroid hormones.
- Fatigue
- Weight gain
- Cold intolerance
Hyperthyroidism (Graves disease)
ModerateOveractive thyroid, most commonly caused by autoimmune Graves disease.
- Weight loss
- Heat intolerance
- Tremor
Hashimoto's Thyroiditis
Mild To ModerateChronic autoimmune inflammation of the thyroid leading to hypothyroidism.
- Fatigue
- Neck swelling
- Cold sensitivity
Addison's Disease
SeverePrimary adrenal insufficiency causing deficient cortisol and aldosterone production.
- Weakness
- Weight loss
- Low blood pressure
Cushing's Syndrome
Moderate To SevereExcess cortisol exposure from endogenous overproduction or exogenous sources.
- Central obesity
- Moon face
- Purple striae
Polycystic Ovary Syndrome (PCOS)
VariableHormonal disorder causing ovarian cysts, hyperandrogenism, and ovulatory dysfunction.
- Irregular periods
- Excess hair growth
- Acne
Primary Hyperparathyroidism
Mild To ModerateOverproduction of parathyroid hormone leading to hypercalcemia.
- Kidney stones
- Bone pain
- Fatigue
Hypoparathyroidism
ModerateInsufficient parathyroid hormone causing low calcium levels.
- Muscle cramps
- Tingling sensations
- Seizures
Pheochromocytoma
SevereCatecholamine‑producing tumor of the adrenal medulla.
- Headache
- Sweating
- Palpitations
Acromegaly
ModerateExcess growth hormone after epiphyseal closure causing tissue overgrowth.
- Enlarged hands/feet
- Facial coarsening
- Joint pain
Gigantism
SevereExcess growth hormone before epiphyseal closure leading to extreme height.
- Rapid linear growth
- Large hands/feet
- Headaches
Primary Hypogonadism (Male)
ModerateTesticular failure resulting in low testosterone production.
- Reduced libido
- Infertility
- Muscle loss
Primary Ovarian Failure
ModerateLoss of ovarian function before age 40, causing estrogen deficiency.
- Irregular periods
- Hot flashes
- Infertility
Hyperprolactinemia
Mild To ModerateElevated prolactin levels that can disrupt reproductive function.
- Galactorrhea
- Menstrual irregularities
- Decreased libido
Central Diabetes Insipidus
VariableDeficiency of antidiuretic hormone (ADH) from the hypothalamus/pituitary.
- Excessive thirst
- Large volumes of dilute urine
- Nighttime urination
Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)
Moderate To SevereExcess ADH release causing water retention and hyponatremia.
- Nausea
- Headache
- Confusion
Primary Hyperaldosteronism (Conn's Syndrome)
ModerateAldosterone overproduction leading to sodium retention and potassium loss.
- High blood pressure
- Muscle weakness
- Frequent urination
Multiple Endocrine Neoplasia Type 1 (MEN1)
VariableInherited syndrome causing tumors of the parathyroid, pancreas, and pituitary.
- Kidney stones
- Peptic ulcers
- Headaches
Multiple Endocrine Neoplasia Type 2 (MEN2)
SevereInherited disorder predisposing to medullary thyroid carcinoma, pheochromocytoma, and parathyroid hyperplasia.
- Neck mass
- High blood pressure
- Palpitations
Congenital Adrenal Hyperplasia
VariableGenetic enzyme defects impairing cortisol synthesis, leading to excess androgen production.
- Ambiguous genitalia
- Early puberty
- Salt-wasting
Insulinoma
ModerateRare pancreatic beta‑cell tumor that secretes insulin autonomously.
- Sweating
- Confusion
- Weakness
Papillary Thyroid Cancer
Mild To ModerateThe most common thyroid malignancy, often linked to radiation exposure.
- Neck lump
- Hoarseness
- Difficulty swallowing
Medullary Thyroid Carcinoma
Moderate To SevereNeuroendocrine tumor of thyroid C‑cells, can be sporadic or part of MEN2.
- Neck nodule
- Diarrhea
- Flushing
Parathyroid Adenoma
Mild To ModerateBenign tumor of a parathyroid gland causing primary hyperparathyroidism.
- Kidney stones
- Bone pain
- Fatigue
Pituitary Adenoma (Non‑functioning)
VariableBenign pituitary tumor that does not secrete hormones but may cause mass effects.
- Headache
- Vision loss
- Hormone deficiencies
Growth Hormone Deficiency
Mild To ModerateInsufficient secretion of growth hormone leading to short stature and metabolic issues.
- Reduced growth velocity
- Increased body fat
- Low energy
Hypothalamic Amenorrhea
Mild To ModerateLoss of menstrual cycles due to hypothalamic suppression often from stress or low body weight.
- Absent periods
- Low libido
- Fatigue
Thyroid Nodules (Benign)
MildSolid or cystic growths within the thyroid gland that are non‑cancerous.
- Neck lump
- Difficulty swallowing
- Hoarseness (rare)
When to Seek Medical Help
For endocrine conditions, consult a healthcare provider if you experience:
- Persistent or worsening symptoms
- Sudden onset of severe symptoms
- Symptoms that interfere with daily activities
- Signs of infection (fever, swelling, redness)
- Unexplained changes or new symptoms
Medical Disclaimer
Medical Disclaimer: The information provided on this website is for general informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. If you think you may have a medical emergency, call your doctor, go to the emergency department, or call 911 immediately.